Her Royal Highness was born 4 September 1896 in Athens. She was a Greek aristocrat who became the wife of HM King Alexander of the Hellenes. Princess Aspasia was the daughter of Colonel Petros Manos, aide-de-camp of King Constantine I of Greece, and Maria Argyropoulos. Both her parents were the descendants of the most prominent Greek Phanariote families of Constantinople and the descendants of the ruling Princes of Wallachia and Moldavia. Princess Aspasia grew up close to the Greek Royal Family.

King Alexander married Aspasia Manos on 17 November 1919, and he was bitten by a domestic monkey and died of sepsis. Aspasia Manos became Princess Aspasia of Greece and Denmark after King Alexander’s death and the restoration of King Constantine I, on 10 September 1922.

King Alexander and Princess Aspasia had a daughter Princess Alexandra of Greece and Denmark born posthumously 21 March 1921. Princess Aspasia spent World War II in England. In 1944, her daughter Princess Alexandra married King Peter II of Yugoslavia, and Aspasia became a grandmother with the birth of Crown Prince Alexander 17 July 1945.

Princess Aspasia died 7 august 1972 in Venice and was buried in San Michele island then in 1993 the Royal Cemetery Tatoi Palace, Greece.